____ are changes in the DNA that can result in no protein or an altered protein being synthesised. Single gene mutations involve the change in a ____ sequence as a result of the substitution, insertion or deletion of nucleotides. There are three substitution mutations- missense, ____ and splice-site mutations. ____ mutations result in one amino acid being changed for another. This may result in non-functional protein or have little effect on the protein. Nonsense mutations result in a ____ being produced which results in a ____ protein. ____ mutations result in some introns being ____ and/or some exons not being included in the mature transcript. There are two types of ____ mutations- nucleotide insertions and deletions. An insertion mutation is when one or more nucleotides are ____ into the DNA sequence of a gene. A deletion mutation is when one or more nucleotides are ____ from the DNA sequence of a gene. Both types of frame-shift mutations cause all of the ____ in the DNA and all of the ____ in the protein after the mutation to be changed. This has a ____ effect on the structure of the protein produced.

Single Gene Mutations Missing Words

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