1) The drug acts by binding to ergosterol and forming pore-forming complexes, resulting in a change in membrane permeability allowing leakage of ions (Na+, K+, Cl-, H+)What is the mechanism of action of Amphotericin B? a) Terbinafine b) Fflucytosine c) Amphotericin B d) Caspofungin 2) Inhibition of squalene epoxidase results in the accumulation of the sterol squalene, which is toxic to the fungal organism a) Terbinafine b) Fflucytosine c) Amphotericin B d) Posaconazole 3) Inhibit fungal cell wall synthesis by inhibiting the synthesis of β(1-3)-glucan, resulting in disruption of the fungal cell wall and cell death a) Caspofungin b) Fflucytosine c) Amphotericin B d) Posaconazole 4) Blocks demethylation of lanosterol to ergosterol, disrupts membrane structure/function fungi a) Posaconazole b) Fflucytosine c) Caspofungin d) Amphotericin B 5) The drug may cause chills, kidney failure, hypotension, anemia... a) Amphotericin B b) Caspofungin c) Flucytosine d) Posaconazole 6) The drug may cause minor GI upset, QT prolongation, hepatotoxicity, drug hypersensitivity... a) Amphotericin B b) Caspofungin c) Flucytosine d) Fluconazole 7) The drug may cause gastrointestinal disturbance, loss of appetite, dizziness, shortness of breath... a) Terbinafine b) Flucytosine c) Caspofungin d) Amphotericin B

Antifangals

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