1) Which of the following immunoglobulins are secretory and present in the milk? a) IgG b) IgM c) IgE d) IgA 2) The specificity of an antibody is due to * a) Its valence b) The heavy chains c) The Fc portion of the molecule d) The variable portion of the heavy and light chain 3) The class of antibodies, which can cross placenta is a) IgD b) IgA c) IgM d) IgG 4) Name the class of immunoglobulin which takes part in hypersensitivity reaction? a) IgG b) IgE c) IgA d) IgM 5) The immobilized enzyme produced by microencapsulation technique provides ? a) An extremely large surface area b) Smaller surface area c) High amount of solvent d) Relatively smaller surface area 6) Which of the following is considered as a disadvantage to the adsorption method of immobilization? a) It is possible to separate and purify the enzymes while being immobilized b) The enzymes are not usually deactivated by adsorption c) The adsorption is a reversible process d) State of immobilization is very sensitive to solution pH, ionic strength and temperature 7) In which of the technique enzyme and polymer are bridged by the use of bi-functional reagent? a) Covalent cross-linking b) Adsorption c) Physical entrapment d) Microencapsulation 8) Which biosensors work on the principle of change in mass ? a) Optical b) Calorimetric c) Colorimetric d) Piezoelectric 9) Glucose Biosensor is an example of .............................biosensor  a) Thermal b) Optical c) Amperometric d) Conductometric 10) Plasmid is the circular piece of DNA present in a) Virus b) Fungi c) Bacteria d) Algae 11) The PCR technique was developed by a) Karry Mullis b) Kohler c) Milstein d) Boyer 12) Introduction of recombinant DNA into the bacterial cell by using current is called a) Transformation b) Electroporation c) Biotransformation d) Transduction 13) In the production of the Hormone-Insulin using rDNA technology, the formed recombinant DNA is introduced into a) Bacteria b) Fungi c) Yeast d) Virus 14) Name the type of culture which is prepared by inoculating directly from the tissue of an organism to culture media a) a) Primary cell culture b) b) Secondary cell culture c) c) Cell lines d) d) Transformed cell culture 15) What is a cell line? a) a) Multilayer culture b) b) Transformed cells c) c) Multiple growth of cells d) d) Sub culturing of primary culture 16) Which of the following is the true characteristics of a normal cell? a) a) Anchorage independent b) b) Continuous cell lines c) c) have a finite number of cell lines d) d) No contact inhibition 17) B cells that produce and release large amounts of antibody are called a) a) Memory cells b) b) Basophils c) c) Plasma cells d) d) Killer cells 18) Type IV hypersensitivity is also called as a) a) Immediate hypersensitivity b) b) Cytotoxic hypersensitivity c) c) Immune complex hypersensitivity d) d) Delayed hypersensitivity 19) Which hypersensitivity reactions are T cell mediated? a) a) Type IV b) b) Type III c) c) Type I d) d) Type II 20) Which of the following is considered an autoimmune disease? a) a) Agammaglobulinemia b) b) AIDS c) c) SCID d) d) Rheumatoid Arthritis 21) A positive tuberculin test is an example of a) a) Delayed type hypersensitivity b) b) Acute contact dermatitis c) c) Type I hypersensitivity d) d) Eczema 22) Naturally acquired active immunity would be most likely acquired through which of the following processes? a) a) Vaccination b) b) Drinking colostrum c) c) Natural birth d) d) Infection with disease causing organism followed by recovery 23) Which of the following antibodies is predominantly present in tears, saliva and mucous a) a) IgM b) b) IgG c) c) IgE d) d) IgA 24) Antigen binding sites are present in a) a) Fab regions of an antibody b) b) Fc region of an antibody c) c) only in the light chain d) d) only in the heavy chain 25) Which enzyme is used to join together two different types of DNA molecules? a) a) ligase b) b) endonuclease c) c) exonuclease d) d) protease 26) Which of the following enzymes in bacteria are responsible for restricting the growth of viruses? a) a) restriction endonuclease b) b) topoisomerase c) c) gyrase d) d) protease 27) Excision and insertion of a gene is called a) a) Biotechnology b) b) Genetic engineering c) c) Cytogenetics d) d) Gene therapy 28) The first clinical application of gene therapy over a 4-year-old girl was for a) a) Adenosine deaminase deficiency b) b) Adenosine deficiency c) c) Growth deficiency d) d) Adenine deficiency 29) Which of the following is the first transgenic crop? a) a) Flax b) b) Tobacco c) c) Plastic d) d) Cotton 30) The first transgenic plant to be produced is a) a) Brinjal b) b) Tobacco c) c) Rice d) d) Cotton 31) Southern blotting is a) a) Attachment of probes to DNA fragments b) b) Transfer of DNA fragments from electrophoretic gel to a nitrocellulose sheet c) c) Comparison of DNA fragments to two sources d) d) Transfer of DNA fragments to electrophoretic gel from cellulose membrane 32) Restriction enzymes were discovered by a) a) Smith and Nathans b) b) Alexander Fleming c) c) Berg d) d) Watson and crick 33) RFLP stand for a) a) Restriction fragment length polymorphism. b) b) Restriction length polymerase. c) c) Restricted fragment live polymorphism. d) d) Rapid fragment length polymorphism. 34) Chain termination is a type of a) a) Sequencing b) b) Vector generation. c) c) Antibiotic production d) d) Gene manipulation 35) . In which of the technique enzyme and polymer are bridged by the use of bi-functional reagent a) a) Covalent cross-linking b) b) Adsorption c) c) Physical entrapment d) d) Microencapsulation 36) The most commonly employed cross – linked polymer is the a) a) Polyacrylamide gel b) b) Collagen c) c) Celluloses d) d) Resin 37) For more complex reactions immobilized ______will be used a) a) Cell b) b) Enzyme c) c) Both A and B d) d) RNA 38) Which medium is used for the production of Penicillin using immobilized cells a) a) 1% peptone medium b) b) glucose medium c) c) Yeast extract medium d) d) LB broth 39) Home blood glucose sensor works on which principle? a) a) electro-physiological b) b) electrochemical c) c) physio-chemical d) d) chemical 40) Antibodies are a) a) Prostaglandins b) b) Steroids c) c) Lipoprotein d) d) Glycoprotein 41) Interferons are a) a) Antibiotic protein b) b) Antiviral protein c) c) Antigen protein d) d) All of the above 42) The class of antibodies, which can cross the placenta is a) a) IgD b) b) IgA c) c) IgG d) d) IgM 43) Very low dose of antigen may induce a) a) hypersensitivity b) b) immunological ignorance c) c) low zone tolerance d) d) low zone immunity 44) Which type of hypersensitivity reaction is auto-immunity? a) a) type –I b) b) type II c) c) type III d) d) type IV 45) Which of the following scientists created the first bioinformatics database? a) a) Dayhoff b) b) Richard Michaell c) c) Michal Durbin d) d) Pearson 46) The identification of drug through the genomic study is called a) a) Pharmacogenomic b) b) Pharmacogenetics c) c) Genomics d) d) Chemoinformatic 47) Proteomics refers to the study of a) a) set of proteins in a specific region of the cell b) b) biomolecules c) c) set of proteins d) d) the entire set of expressed protein in the cell. 48) The process of finding the relative location of genes on a chromosome is called a) a) gene tracking b) b) genome walking c) c) chromosome walking d) d) genome mapping 49) The term “invitro” is the Latin word which refers to a) a) within the lab b) b) within the glass c) c) outside the lab d) d) outside the glass 50) Probe is a -------------------- a) Protein for detecting a specific DNA molecule b) Short piece of labeled DNA which are complementary to the nucleic acid strand to be detected c) Protein for detecting a specific RNA molecule d) Short piece of labeled DNA or RNA which is complementary to the nucleic acid

Pharmaceutical Biotechnology

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