Heritability - Can be calculated using the concordance between monozygotic and dizygotic twins, Recurrence risk ratio - Can be calculated using prevalence of disease in family members and the general population, Dizygotic twins - Share 50% of their DNA and 100% of their initial environment, Monozygotic twins - Share 100% of their DNA and 100% of their initial environment, Germline variants - Occur in every cell of the body, Somatic variants - Absent in gamete, can occur at any time during development or after birth,

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