Celecoxib (Celebrex): MOA: Selectively inhibits COX-2 enzymes without inhibition of COX-1, USE: decrease inflammation and pain , TREATS: OA/RA, SE/AR: Peripheral edema, cough, dyspepsia, and pain, Advantages: Patients who need high doses of anti-inflammatory drugs (arthritis) and decreased risk of GI bleeding, Corticosteroids: Prednisone: Control inflammation by suppressing or preventing many of the components of the inflammatory process at the injured site, Not the drug of choice for arthritis because of its numerous side effects, Frequently used to control arthritic flare-ups , Needs to be Tapered off, Methotrexate : Antimetabolite , MOA: inhibition of enzymes responsible for nucleotide synthesis, USE: Rheumatoid arthritis and Psoriasis, SE: Mucosal ulcers and loss of appetite, AR: Hepatotoxicity , Monitor for black/tarry stools, bleeding gums, loss of appetite, and infection, Avoid NSAIDs and pregnancy , Adalimumab (Humira): MOA: Inhibit tumor necrosis factor ALPHA (TNF-A) , USE: reduce joint swelling, tenderness, inflammation, slow joint destruction in rheumatoid arthritis, Crohn's, UC, plaque, psoriasis , Route: subq x1 month, SE: Blurred vision, joint pain, bloody urine, diarrhea, and chest pain, Cyclosporine (Gengraf): Calcineurin Inhibitor , MOA: Immunosuppressant drug that inhibits the activation + proliferation of T cells, USE: Prevent organ rejection and treat other autoimmune diseases , SE: Increase BUN + Cr, hypertension, infection, gingival overgrowth, immunosuppression, and hyperkalemia, Avoid grapefruit juice, Contraindications: Uncontrolled HTN, hepatic impairment, concurrent nephrotoxic agent use, Allopurinol (Zyloprim): Uric Acid Inhibitors, MOA: decrease the production of uric acid, prophylactic to prevent gout attacks, Monitor CBC, liver enzymes, and renal function , Yearly eye exams , Advise pt to increase fluid intake to increase uric acid excretion,

Inflammatory + Immunity pt.2

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