Herpes: Acyclovir Sodium: MOA: interferes with the steps of viral DNA synthesis , USE: HSV-1, HSV-2, Varicella Zoster Virus, ROUTE: PO/IV, topical, NEVER IV push , SE: Hepatotoxicity, Nephrotoxicity, n/v/d, headache, skin irritation, and rash, TEACHING: take with food, ensure hydration, and how to avoid spreading the virus , HIV infection: RNA Retrovirus , Can't survive or replicate without a living human cell, Destroys CD4+t CELLS , CD4 cell count: Indicator of immune function in those with HIV, Destruction = immune deficiency , Stages of HIV infection: Acute infection: large amounts of virus produced "worst flu ever", Clinical latency: low levels produced, but still active, not showing any symptoms lasting up to 8 yrs, AIDs: CD4 cells fall below 200 now diagnosed as having AIDs, without treatment, the typical survival rate < 3 yrs, Transmission of HIV: Sexual contact, Direct blood contact- IV, razors , Mother to child: direct blood contact during delivery, breast milk, shared circulation, Treatment Goals of ART: Reduced morbidity and mortality , Prolonged the duration and quality of life, Restore and preserve immunologic function, Suppress plasma HIV (Viral load), Prevent HIV transmission, NRTIs: Zidovudine (AZT, Retrovir): MOA: Inhibits viral enzymes needed for viral replication, SE/AR: N/D, abdominal pain, rash, peripheral neuropathy, pancreatitis, lipoatrophy, hepatotoxicity, renal impairment, myelosuppresion , Considerations: with/without food, limited interactions, The first type of drug to treat HIV works early in the virus’s life cycle by stopping it from copying its genetic material, Indinavir (Crixivan): MOA: Inhibits protease activity, affecting the final assembly of new virions, SE: Rash, N/V/D, dyslipidemia, insulin resistance, hemolytic anemia, SJS, EKG changes, MI, Has many drug interactions,

Herpes + HIV pt.1

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